Research | Measures of Cognitive Impairment

Developing measures of cognitive impairment in the real world from consumer-grade multimodal sensor streams

ABSTRACT: The ubiquity and remarkable technological progress of wearable consumer devices and mobile-computing platforms (smart phone, smart watch, tablet), along with the multitude of sensor modalities available, have enabled continuous monitoring of patients and their daily activities. Such rich, longitudinal information can be mined for physiological and behavioral signatures of cognitive impairment and provide new avenues for detecting MCI in a timely and cost-effective manner. In this work, we present a platform for remote and unobtrusive monitoring of symptoms related to cognitive impairment using several consumer-grade smart devices. We demonstrate how the platform has been used to collect a total of 16TB of data during the Lilly Exploratory Digital Assessment Study, a 12-week feasibility study which monitored 31 people with cognitive impairment and 82 without cognitive impairment in free living conditions. We describe how careful data unification, time alignment, and imputation techniques can handle missing data rates inherent in real-world settings and ultimately show utility of these disparate data in differentiating symptomatics from healthy controls based on features computed purely from device data.

Read the full paper here.

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Bertina Yen, Evidation's Senior Vice President of People & Community

Bertina Yen is Evidation's Senior Vice President of People & Community, where she is responsible for the end-to-end employee experience and building a community that supports everyone's ability to show up as their authentic selves and perform their best work. Prior to joining Evidation, Bertina served as EVP overseeing clinical teams, product management, marketing, and product development at Zynx Health, driving development of evidence-based clinical decision support solutions that improve health and financial outcomes.

Bertina received her BAS from Stanford, then completed her MD and residency in internal medicine at UC San Diego. She also holds an MPH in health services administration from UCLA.

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Publications & Abstracts

Developing measures of cognitive impairment in the real world from consumer-grade multimodal sensor streams

Read the full paper here.

Related Therapeutic Areas:

Neurology